• The Crowston Lab

Aims

We aim to understand the underlying mechanism of eye diseases, especially in glaucoma, and look for therapeutic strategies for vision recovery.

Focus

We focus on glaucoma disease, looking at the eye injury response and recovery process, as well as the underlying molecular and cellular mechanisms.

Strategies

Using both in vivo and in vitro models, combine with different cutting-edge technologies and technique to reveal neural functional recovery process.

Findings

We have discovered that retinal ganglion cells in mice enter into a “comatose” non-functional state after injury but retain the capacity for functional recovery.

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About the Group Leader:

Dr. Jonathan Crowston

Professor of Ophthalmology
Centre for Vision Research, Duke-NUS Medical School and Singapore Eye Research Institute
Neuroscience and Behavioural Disorder Programme, Duke-NUS Medical School

Dr. Jonathan Crowston obtained his medical degree at the Royal Free Hospital SOM, London, and a PhD at University College London. Following ophthalmology training at Moorfields Eye Hospital, he completed glaucoma fellowships at Westmead Hospital in Sydney and the University of California, San Diego. He was subsequently appointed as a faculty member in the University of California, San Diego, and served as Director of the Hamilton Glaucoma Center Basic Research Laboratories. He moved to Melbourne in July 2006 and established the Glaucoma Research Laboratory at the Centre for Eye Research Australia (CERA). He was subsequently appointed as Head of Ophthalmology at the University of Melbourne and Director of CERA. His research focuses on understanding why ageing predisposes individuals to optic nerve damage in glaucoma, and developing new therapeutic approaches to boost neuronal repair.

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Science

Our Research

In vivo Neuron Recovery Model

We have developed an in vivo mouse eye injury model to investigate the impact of exercise on aged retina and optic nerve, as well as its response to injury.

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In Vitro Cell Culture Study

We are looking at generating in vitro cell culture systems to study the neuron protective processes, mechanisms, and both intrinsic and extrinsic contributions.

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Single-cell Based Omics Study

Using the cutting-edge technology of single-cell genomics, we are mining the molecular secrets behind retinal injury response and recovery process.

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Team

Our Scientists

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Dr. Jonathan Crowston

Professor
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Dr. Katharina Bell

Collaborating PI
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Dr. Vicki Chrysostomou

Senior Research Fellow
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Dr. Marion Millet

Research Fellow