• The Crowston Lab

Our Publications

Our Publications

Our research focuses on understanding why advancing age predisposes individual to retinal ganglion cell (RGC) loss and from this determine new therapeutic approaches for optic nerve protection. We discovered that RGC in mice enter a “comatose” non-functional state after injury but retains the capacity for functional recovery. Diet restriction and exercise profoundly improve the rate of functional recovery and synapse reformation. We seek to uncover key pathways involved in driving neurorecovery. Another key area of our research is to develop diagnostic tests that will inform on the state of RGC health.

  1. Tribble JR, Hui F, Jöe M, Bell K, Chrysostomou V, Crowston JG, Williams PA. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021;10(2):295.
  2. Shah MH, Chan EC, Van Bergen NJ, Pandav SS, Ng S, Crowston JG, et al. Nox4 Facilitates TGFbeta1-Induced Fibrotic Response in Human Tenon's Fibroblasts and Promotes Wound Collagen Accumulation in Murine Model of Glaucoma Filtration Surgery. Antioxidants (Basel). 2020;9(11):1126.
  3. Foreman J, Crowston JG, Dirani M. Is physical activity protective against myopia? Br J Ophthalmol. 2020;104(10):1329-30.
  4. Kadziauskiene A, Chua J, Baskaran M, Yow AP, Tan B, Sng C, et al. Association Between Structure-function Characteristics and Visual Field Outcomes in Glaucoma Subjects with Intraocular Pressure Reduction After Trabeculectomy. J Glaucoma. 2020;29(8):648-55.
  5. Kezic JM, Chrysostomou V, McMenamin PG, Crowston JG. Effects of age on retinal macrophage responses to acute elevation of intraocular pressure. Exp Eye Res. 2020;193:107995.
  6. Chua J, Kadziauskiene A, Wong D, Asoklis R, Lesinskas E, Quang ND, et al. One year structural and functional glaucoma progression after trabeculectomy. Sci Rep. 2020;10(1):2808.
  7. Ang GS, Fenwick EK, Constantinou M, Gan ATL, Man REK, Casson RJ, et al. Selective laser trabeculoplasty versus topical medication as initial glaucoma treatment: the glaucoma initial treatment study randomised clinical trial. Br J Ophthalmol. 2020;104(6):813-21.
  8. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez MIG, Johanssen VA, Cook MJ, et al. Correction to: Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. Mol Neurobiol. 2019;56(10):7249.
  9. Yan MK, Kumar H, Kerr N, Medeiros FA, Sandhu SS, Crowston J, et al. Transnational review of visual standards for driving: How Australia compares with the rest of the world. Clin Exp Ophthalmol. 2019;47(7):847-63.
  10. Wu Z, Crabb DP, Chauhan BC, Crowston JG, Medeiros FA. Improving the Feasibility of Glaucoma Clinical Trials Using Trend-Based Visual Field Progression Endpoints. Ophthalmol Glaucoma. 2019;2(2):72-7.
  11. Kwon HJ, Kumar H, Green CM, Crowston JG, McGuinness MB, Kerr NM. Bleb-associated endophthalmitis: Proportion, presentation, management and outcomes in Victoria, Australia. Clin Exp Ophthalmol. 2019;47(5):588-97.
  12. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez MIG, Johannsen VA, Cook MJ, et al. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. Mol Neurobiol. 2019;56(8):5471-82.
  13. Hadoux X, Hui F, Lim JKH, Masters CL, Pebay A, Chevalier S, Ha J, Loi S, Fowler CJ, Rowe C, Villemagne VL, Taylor EN, Fluke C, Soucy JP, Lesage F, et al. Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease. Nat Commun. 2019;10(1):4227.
  14. Fry LE, Fahy E, Chrysostomou V, Hui F, Tang J, van Wijngaarden P, Petrou S, Crowston JG. The coma in glaucoma: Retinal ganglion cell dysfunction and recovery. Prog Retin Eye Res. 2018;65:77-92.
  15. Crowston J, Trounce I. Relief for retinal neurons under pressure. Science. 2017;355(6326):688-9.
  16. Chrysostomou V, Galic S, van Wijngaarden P, Trounce IA, Steinberg GR, Crowston JG. Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway. Aging Cell. 2016;15(6):1082-91.
  17. Chrysostomou V, Kezic JM, Trounce IA, Crowston JG. Forced exercise protects the aged optic nerve against intraocular pressure injury. Neurobiol Aging. 2014;35(7):1722-5.
  18. Crowston JG, Kong YX, Trounce IA, Dang TM, Fahy ET, Bui BV, Morrison JC, Chrysostomou V. An acute intraocular pressure challenge to assess retinal ganglion cell injury and recovery in the mouse. Exp Eye Res. 2015;141:3-8.
  19. O'Neill EC, Gurria LU, Pandav SS, Kong YX, Brennan JF, Xie J, Coote MA, Crowston JG. Glaucomatous optic neuropathy evaluation project: factors associated with underestimation of glaucoma likelihood. JAMA Ophthalmol. 2014;132(5):560-6.
  20. Chrysostomou V, Crowston JG. The photopic negative response of the mouse electroretinogram: reduction by acute elevation of intraocular pressure. Invest Ophthalmol Vis Sci. 2013;54(7):4691-7.
  21. Kong YX, van Bergen N, Bui BV, Chrysostomou V, Vingrys AJ, Trounce IA, Crowston JG. Impact of aging and diet restriction on retinal function during and after acute intraocular pressure injury. Neurobiol Aging. 2012;33(6):1126 e15-25.
  22. Kong YX, Van Bergen N, Trounce IA, Bui BV, Chrysostomou V, Waugh H, Vingrys A, Crowston JG. Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury. Aging Cell. 2011;10(4):572-83.
  23. Van Bergen NJ, Wood JP, Chidlow G, Trounce IA, Casson RJ, Ju WK, Weinreb RN, Crowston JG. Recharacterization of the RGC-5 retinal ganglion cell line. Invest Ophthalmol Vis Sci. 2009;50(9):4267-72.
  24. ong YX, Crowston JG, Vingrys AJ, Trounce IA, Bui VB. Functional changes in the retina during and after acute intraocular pressure elevation in mice. Invest Ophthalmol Vis Sci. 2009;50(12):5732-40.
  25. Crowston JG, Akbar AN, Constable PH, Occleston NL, Daniels JT, Khaw PT. Antimetabolite-induced apoptosis in Tenon's capsule fibroblasts. Invest Ophthalmol Vis Sci. 1998;39(2):449-54.